![]() ![]() We expect that LimeMap will contribute to elucidating the comprehensive functional relationships and pathways of lipid mediators. Users will be able to modify the map and visualize measured data specific to their purposes using CellDesigner and VANTED software. Ultimately, LimeMap comprises 282 factors (222 mediators, and 60 enzymes, receptors, and ion channels) and 279 reactions derived from 102 related studies. We constructed the map by focusing on ω-3 and ω-6 fatty acid metabolites and their respective metabolic pathways, with manual curation of referenced information from public databases and relevant studies. Here, we have built a precise map of lipid mediator metabolic pathways (LimeMap) to visualize the comprehensive profiles of lipid mediators that change dynamically in various disorders. Against this background, a knowledge-based pathway map of lipid mediators would be useful to visualize and understand the overall interactions of these factors. Such systematic approaches have enabled us to identify key changes of biological relevance. Recent lipidomics approaches have made it possible to analyze multiple metabolites and the associations of individual lipid mediators. Lipid mediators are major factors in multiple biological functions and are strongly associated with disease. ![]()
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